Cancer Weekly
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Gene Therapy
Study findings from Mie University, Medical Department broaden understanding of gene therapy
July 15th, 2008
According to recent research from Tsu, Japan, "In adoptive T-cell transfer as an intervention for malignant diseases, retroviral transfer of T-cell receptor ( TCR) genes derived from CD8(+) cytotoxic T-lymphocyte ( CTL) clones provides an opportunity to generate a large number of T cells with the same antigen specificity. We cloned the TCR-alpha beta genes from a human leukocyte antigen ( HLA)- A*2402 restricted CTL clone specific for MAGE- A4(143-151)." "The TCR-alpha beta genes were transduced to 99.2% of non-TCR expressing SupT1, a human T-cell line, and to 12.7-32.6% of polyclonally activated CD8+ T cells by retroviral transduction. As expected, TCR-alpha beta gene-...
Source: Cancer Weekly (2008-07-15)
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