Cancer Weekly
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Angiogenesis
New research on angiogenesis from American University of Beirut summarized
July 15th, 2008
"Kaposi's sarcoma-associated herpesvirus ( KSHV) is the causative agent of primary effusion lymphoma (PEL) and of Kaposi's sarcoma. PEL is an aggressive proliferation of B cells with poor prognosis," scientists in Beirut, Lebanon report. "We evaluated both in vitro and in vivo the potential role of angiogenic factors secreted by PEL cells, that is, their interaction with endothelial cells and their implication in the invasive behavior of tumoral cells. In vitro, PEL-induced angiogenesis is dependent on vascular endothelial growth factor ( VEGF) and VEGF receptors. However, although PEL cells produce VEGF and basic fibroblast growth factor (b-FGF) transcripts, they only...
Source: Cancer Weekly (2008-07-15)
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