Cancer Weekly
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Ataxia Telangiectasia
Report summarizes ataxia telangiectasia study findings from Children's Hospital
July 15th, 2008
According to recent research from the United States, "Significant progress has been made in recent years in elucidating the molecular controls of cellular responses to DNA damage in mammalian cells. Much of our understanding of the mechanisms involved in cellular DNA damage response pathways has come from studies of human cancer susceptibility syndromes that are altered in DNA damage responses." "Ataxia-telangiectasia mutated (ATM), the gene mutated in the disorder ataxia-telangiectasia, codes for a protein kinase that is a central mediator of responses to DNA double-strand breaks (DSB) in cells. Once activated, ATM phosphorylates numerous substrates in the cell that...
Source: Cancer Weekly (2008-07-15)
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