Cancer Weekly
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Cancer Gene Therapy
Report summarizes cancer gene therapy study findings from Y. Sasaki and co-researchers
July 15th, 2008
According to recent research from Sapporo, Japan, "Therapeutic replacement of the wild-type p53 gene has been pursued as a potential gene therapy strategy in a variety of cancer types; however, some cancer models are resistant to p53 in vivo and in vitro. Therefore, to improve p53 gene therapy, it is important to overcome the resistance to p53-mediated apoptosis." "Histone deacetylase inhibitors are a novel class of chemotherapeutic agents that are able to reverse the malignant phenotype of transformed cells. A natural histone deacetylase inhibitor, FK228, is reported to enhance adenovirus infection due in part to the up-regulation of coxsackievirus adenovirus receptor...
Source: Cancer Weekly (2008-07-15)
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