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Cancer Gene Therapy
Yonsei University publishes research in cancer gene therapy
July 15th, 2008
"RNA interference, due to its target specificity, may be highly effective as a novel therapeutic modality, but direct delivery of synthetic small interfering RNA still remains a major obstacle for this approach. To induce long-term expression and specific gene silencing, novel delivery vector system is also required," scientists in Seoul, South Korea report. "In this study, we have generated an efficient oncolytic adenovirus ( Ad)- based short hairpin ( shRNA) expression system (Ad-Delta B7- U6shIL8) against IL-8, a potent proangiogenic factor. To demonstrate IL-8- specificity of this newly engineered Ad-based shRNA, we also manufactured replication- incompetent Ads...
Source: Cancer Weekly (2008-07-15)
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