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Cancer Gene Therapy
Louisiana State University, University Health Science Center publishes research in cancer gene therapy
July 22nd, 2008
Research findings, 'eIF4E-targeted suicide gene therapy in a minimal residual mouse model for metastatic soft-tissue head and neck squamous cell carcinoma improves disease-free survival,' are discussed in a new report. According to a study from the United States, "Translation initiation factor eIF4E unwinds long 5'-untranslated regions of certain tightly regulated mRNAs and, thereby, facilitates their translation into proteins. eIF4E has been shown to be overexpressed in a majority of solid tumors, including head and neck cancers. To exploit this dysregulation, a long 5'-untranslated region was spliced upstream of a thymidine kinase (Tk) gene to enhance translation of this 'suicide' gene...
Source: Cancer Weekly (2008-07-22)
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