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Cancer Gene Therapy
Studies from Cold Spring Harbor Laboratory describe new findings in cancer gene therapy
July 22nd, 2008
Researchers detail in 'DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma,' new data in cancer gene therapy. "Deletions on chromosome 8p are common in human tumors, suggesting that one or more tumor suppressor genes reside in this region. Deleted in Liver Cancer 1 (DLC1) encodes a Rho-GTPase activating protein and is a candidate 8p tumor suppressor," scientists writing in the journal Genes & Development report. "We show that DLC1 knockdown cooperates with Myc to promote hepatocellular carcinoma in mice, and that reintroduction of wild-type DLC1 into hepatoma cells with low DLC1 levels suppresses tumor growth in situ. Cells with...
Source: Cancer Weekly (2008-07-22)
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