Hepatocellular Cancer

Research from University of Rostock in hepatocellular cancer provides new insights

Published in Cancer Weekly, July 22nd, 2008

According to a study from Rostock, Germany, "Hepatitis B virus (HBV) is a causative agent of chronic hepatitis and hepatocellular carcinoma. Recent findings demonstrating p73 and specifically N-terminally truncated p73 (Delta TAp73) accumulation in hepatocellular carcinoma suggest that p73 plays a role in the malignant phenotype."

"Here, we investigated the mechanism of HBV pregenomic core promoter/ enhancer II (cp/EII) regulation by full-length TAp73 and its oncogenic counterpart Delta TAp73. Ectopic and endogenous expression of TAp73 leads to a significant downregulation of cp/EII activity in p53-deficient hepatoma cell lines. In contrast, overexpression of Delta...

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Source: Cancer Weekly (2008-07-22)

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