Cancer Weekly
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Acute Myeloid Leukemia
Studies from Ohio State University yield new data on acute myeloid leukemia
July 22nd, 2008
According to recent research published in the journal Blood, "BAALC expression is considered an independent prognostic factor in cytogenetically normal acute myeloid leukemia (CN-AML), but has yet to be investigated together with multiple other established prognostic molecular markers in CN-AML. We analyzed BAALC expression in 172 primary CN-AML patients younger than 60 years of age, treated similarly on CALGB protocols." "High BAALC expression was associated with FLT3-ITD (P = .04), wild-type NPM1 (P < .001), mutated CEBPA (P = .003), MLL-PTD (P = .009), absent FLT3-TKD (P = .005), and high ERGexpression (P = .05). In multivariable analysis, high BAALC...
Source: Cancer Weekly (2008-07-22)
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