Cancer Weekly
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Angiogenesis
New findings from C. Hetzel and co-authors in the area of angiogenesis published
July 22nd, 2008
"The most potent immunotoxins (ITs) developed to date contain bacterial or plant cytotoxic components. As these are potentially immunogenic in man, human proteins are preferred for the long-term treatment of cancer," scientists in Aachen, Germany report. "We have developed the first humanized IT for the treatment of CD64(+) malignancies such as acute myeloid leukemia. The bacterially expressed IT is composed of a humanized anti-CD64 single chain fragment [h22(scFv)] genetically fused to the human RNase angiogenin. As angiogenin lacks a dedicated translocation domain responsible for the higher potency of bacterial and plant-derived toxins, we have incorporated a...
Source: Cancer Weekly (2008-07-22)
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