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Apoptosis
Data from Josai University provide new insights into apoptosis
July 22nd, 2008
"Twenty-six benzocycloheptoxazine derivatives were investigated for their tumor-specific cytotoxicity and apoptosis-inducing activity against three human normal cells (gingival fibroblast HGF, pulp cell HPC, periodontal ligament fibroblast HPLF) and four human tumor cell lines (squamous cell carcinoma HSC-2, HSC-3, HSC-4, promyelocytic leukemia HL-60). Benzo[b]cyclohepta[e][1,4]thiazine [11 exhibited very weak cytotoxicity, whereas its 6,8,10-tribromo derivative [31 exhibited higher cytotoxicity and tumor specificity (TS=5.6). 6H-Benzo[bjcyclohepta[e][1,4]diazine [4] and its cation [51 exhibited no tumor specificity," scientists writing in the journal Anticancer Research...
Source: Cancer Weekly (2008-07-22)
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