Cancer Weekly
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Apoptosis
Research from University of Dublin, Trinity College in the area of apoptosis published
July 22nd, 2008
"The psychoactive ingredient of marijuana, Delta(9)-tetrahydrocannabinol (Delta(9)-THC), can evoke apoptosis in cultured cortical neurones. Whilst the intracellular mechanisms responsible for this apoptotic pathway remain to be fully elucidated, we have recently identified a role for the CB1 type of cannabinoid (CB) receptor and the tumour suppressor protein, p53," scientists in Dublin, Ireland report. "In the current study, we demonstrate the Delta(9)-THC promotes a significant increase in lysosomal permeability in a dose- and time-dependent manner. The increase in lysosomal permeability was blocked by the CB1 receptor antagonist, AM251. Delta(9)-THC increased the...
Source: Cancer Weekly (2008-07-22)
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