Cancer Weekly
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Apoptosis
Researchers from University of Kentucky describe findings in apoptosis
July 22nd, 2008
"Peroxisome proliferators (PPs) are a diverse class of chemicals, which cause a dramatic increase in the size and number of hepatic peroxisomes in rodents and eventually lead to the development of hepatic tumors. Nuclear factor-kappa B (NF-kappa B) is a transcription factor activated by reactive oxygen and is involved in cell proliferation and apoptosis," scientists in the United States report. "Previously we found that the peroxisome proliferator ciprofibrate (CIP) activates NF-kappa B and that dietary vitamin E decreases CIP-induced NF-kappa B DNA binding. We, therefore, hypothesized that inhibition of NF-kappa B by vitamin E is necessary for effects of vitamin E on...
Source: Cancer Weekly (2008-07-22)
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