Cancer Weekly
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Cancer Gene Therapy
New cancer gene therapy research from W.B. Wang et al outlined
July 22nd, 2008
According to recent research from Xiamen, People's Republic of China, "Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene therapy and canstatin gene therapy have been investigated extensively in human xenograft tumor models established in immunocompromised nude mice. However, combination antitumor activity of these two agents and the safety of such gene constructs driven by the human telomerase reverse transcriptase (hTERT) promoter in nude mice have not been well documented." "We hypothesized that TRAIL and canstatin gene therapy driven by the hTERT promoter might overcome the problem of liver toxicity and still effectively induce apoptosis on tumor...
Source: Cancer Weekly (2008-07-22)
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