Cancer Weekly
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Gene Therapy
New gene therapy study findings recently were published by researchers at Fudan University
July 29th, 2008
According to recent research published in the journal Cancer Gene Therapy, "Some anaerobes and facultative anaerobes have been used in tumor-specific gene therapy by reason of their selective growth in tumors. In this work, we aimed to evaluate the anticancer efficacy of attenuated Salmonella typhimurium as a carrier to deliver the Escherichia coli purine nucleoside phosphorylase (ePNP) gene for GDEPT (gene-directed enzyme-prodrug therapy)." "A live attenuated purine-auxotrophic strain of S. typhimurium (SC36) was used to carry the pEGFP-C1-ePNP vector that contains a green fluorescent protein (GFP) and an ePNP gene under the control of the human cytomegalovirus...
Source: Cancer Weekly (2008-07-29)
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