Cancer Weekly
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Immunization
New immunization research from Soochow University described
July 29th, 2008
According to recent research published in the journal Cellular & Molecular Immunology, "A key and limiting step in the process of human monocyte-derived dendritic cells (mDCs) for clinical use is their in vitro maturation and in vivo migration. We previously observed that CD40 signal facilitated human mDC growth and maturation." "To further explore this process, mDCs generated with GM-CSF and IL-4 were co-cultured with apoptotic tumor cells for 24 hours, followed by incubating with anti-CD40 monoclonal antibody or TNF-alpha for 48 hours to generate mature DCs. The chemokine/chemokine receptor expression and functions of mature DCs upon various stimuli were...
Source: Cancer Weekly (2008-07-29)
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