Cancer Weekly
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Angiogenesis
New angiogenesis research from Osaka University described
July 29th, 2008
Researchers detail in 'Fasudil-induced hypoxia-inducible factor-1{alpha} degradation disrupts a hypoxia-driven vascular endothelial growth factor autocrine mechanism in endothelial cells,' new data in angiogenesis. According to recent research from Suita, Japan, "Hypoxic response of endothelial cells (EC) is an important component of tumor angiogenesis. Especially, hypoxia-inducible factor-1 (HIF-1)-dependent EC-specific mechanism is an essential component of tumor angiogenesis." "Recently, the Rho/Rho-associated kinase (ROCK) signaling has been shown to play a key role in HIF-1alpha induction in renal cell carcinoma and trophoblast. The present study was designed to...
Source: Cancer Weekly (2008-07-29)
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