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Cancer Gene Therapy
Data on cancer gene therapy described by investigators at Institute of Cancer Research
July 29th, 2008
Investigators publish new data in the report 'Attenuated salmonella targets prodrug activating enzyme carboxypeptidase G2 to mouse melanoma and human breast and colon carcinomas for effective suicide gene therapy.' "We engineered the oncolytic Salmonella typhimurium-derived bacterium VNP20009 as a vector to target delivery to tumors of the prodrug-activating enzyme carboxypeptidase G2 (CPG2) and to show enhanced antitumor efficacy on administration of different prodrugs. We characterized CPG2 expression in vectors by immunoblotting, immunofluorescence, and enzyme activity," scientists in Sutton, the United Kingdom report. "We assessed prodrug activation by...
Source: Cancer Weekly (2008-07-29)
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