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Cancer Gene Therapy
New cancer gene therapy research from Lowe Center for Thoracic Oncology outlined
July 29th, 2008
Investigators publish new data in the report 'EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer.' "The EML4-ALK fusion gene has been detected in approximately 7% of Japanese non-small cell lung cancers (NSCLC). We determined the frequency of EML4-ALK in Caucasian NSCLC and in NSCLC cell lines," scientists in the United States report. "We also determined whether TAE684, a specific ALK kinase inhibitor, would inhibit the growth of EML4-ALK-containing cell lines in vitro and in vivo. We screened 305 primary NSCLC [both U.S. (n=138) and Korean (n=167) patients] and 83 NSCLC cell lines using reverse transcription-PCR and by exon array analyses. We...
Source: Cancer Weekly (2008-07-29)
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