Cancer Weekly
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Cancer Gene Therapy
New cancer gene therapy study results from University of Pittsburgh, Pittsburgh Cancer Institute described
July 29th, 2008
Investigators publish new data in the report 'Bortezomib induces apoptosis via Bim and Bik up-regulation and synergizes with cisplatin in the killing of head and neck squamous cell carcinoma cells.' "Head and neck squamous cell carcinomas (HNSCC) are characterized by resistance to chemotherapy and overexpression of antiapoptotic Bcl-2 family members, including Bcl-X(L) and Bcl-2. Molecular targeting of Bcl-X(L) and/or Bcl-2 in HNSCC cells has been shown to promote apoptosis signaling and to sensitize cells to chemotherapy drugs, including cisplatin, which is commonly used in the treatment of HNSCC," scientists in the United States report. "We report that induction of...
Source: Cancer Weekly (2008-07-29)
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