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Cancer Gene Therapy
Researchers from Sichuan University, State Key Laboratory of Biotherapy and Cancer Center detail findings in cancer gene therapy
July 29th, 2008
A new study, 'Human alpha-defensin-1 inhibits growth of human lung adenocarcinoma xenograft in nude mice,' is now available. According to a study from Chengdu, People's Republic of China, "Human alpha-defensin-1 (HNP1), a small antimicrobial peptide, shows cytotoxicity to tumor cells in vitro and inhibitory activity for pathologic neovascularization in vivo. Here, we did a gene therapy with a plasmid that expresses a secretable form of HNP1 for assaying its antitumor activity." "The expression and secretion of HNP1 were determined by reverse transcription-PCR and ELISA in vitro. We found that expression of HNP1 in A549 tumor cells caused significant growth inhibition....
Source: Cancer Weekly (2008-07-29)
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