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Cancer Gene Therapy
Study findings from University of Yamanashi, Department of Pathology broaden understanding of cancer gene therapy
July 29th, 2008
A report, 'Epigenetic dysregulation in thyroid neoplasia,' is newly published data in Endocrinology and Metabolism Clinics of North America. "Gain-of-function mutations in oncogenes have aided our understanding of the molecular mechanisms of thyroid carcinogenesis. Mutations or deletions cause inactivation of tumor suppressor genes in thyroid carcinomas," researchers in Japan report. "However, recent advances have disclosed the significance of epigenetic events in the development and progression of human tumorigenesis. Indeed, various tumor-suppressor genes and thyroid hormone-related genes are epigenetically silenced in thyroid tumors. This article reviews the...
Source: Cancer Weekly (2008-07-29)
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