Cancer Weekly
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Angiogenesis
Reports by K. Noma and co-researchers describe recent advances in angiogenesis
July 29th, 2008
According to recent research from the United States, "Esophageal squamous cell carcinoma (ESCC) is known to be a highly angiogenic tumor. Here, we investigated the role of the stromal fibroblasts in the ESCC-induced angiogenic response using a novel 3-dimensional model." "A novel assay was developed where cocultures of ESCC and esophageal. fibroblasts induced human microvascular endothelial cell (HMVEC) vascular network formation in a 3-dimensional collagen gel. Biochemical studies showed that the ESCC-induced activation of the fibroblasts was required to induce vascular network formation via a transforming growth factor (TGF)-beta and vascular endothelial growth factor...
Source: Cancer Weekly (2008-07-29)
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