Cancer Weekly
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Apoptosis
Research findings from University of California, Medical Department update understanding of apoptosis
July 29th, 2008
According to recent research from the United States, "p63 shares considerable sequence identity with p53, especially in its DNA-binding, activation and tetramerization domains. When the upstream promoter is used for p63 expression, three major transactivation p63 (TAp63) isoforms (alpha, beta and gamma) are produced. p63 is also expressed from an alternate promoter located in intron 3, producing three major Delta Np63 isoforms." "Recent studies demonstrated that p63 has the potential to function as a tumor suppressor or an oncoprotein. To further address this, we generated cell lines that inducibly express each TAp63 isoform. We showed that TAp63 isoforms are capable of...
Source: Cancer Weekly (2008-07-29)
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