Cancer Weekly
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Apoptosis
Studies from University of Texas provide new data on apoptosis
July 29th, 2008
According to a study from the United States, "During apoptosis, cytochrome c is released from mitochondria to the cytosol, where it binds Apaf-1. The Apaf-1 /cytochrome c complex then oligomerizes either into heptameric caspase-9-activating apoptosome, which subsequently activates caspase-3 and caspase-7, or bigger inactive aggregates, depending on the availability of nucleotide dATP/ATP." "A tumor suppressor protein, PHAPI, enhances caspase-activation by promoting apoptosome formation through an unknown mechanism. We report here the identification of cellular apoptosis susceptibility protein (CAS) and heat shock protein 70 (Hsp70) as mediators of PHAPI activity. PHAPI,...
Source: Cancer Weekly (2008-07-29)
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