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Cancer Gene Therapy
New cancer gene therapy research has been reported by C.A. Montielequihua et al
July 29th, 2008
"Expression of the sodium iodide symporter (hNIS) has been detected in breast cancer tissue, but frequently, not at the levels necessary to mediate I-131 accumulation. Transducing the hNIS gene into breast cancer cells with adenovirus could be a tractable strategy to render breast cancer susceptible to radioiodide therapy," scientists in London, the United Kingdom report. "We constructed the replication-incompetent virus, AdSERE, in which an estrogen-responsive promoter directs the expression of hNIS. In vitro, we demonstrate that AdSERE mediates hNIS expression and iodide uptake in ER+ breast cancer cells," wrote C.A. Montielequihua and colleagues. ...
Source: Cancer Weekly (2008-07-29)
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