Cancer Weekly
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Cancer Gene Therapy
New cancer gene therapy study results from Central South University described
August 5th, 2008
New research, 'Knocking down Wnt9a mRNA levels increases cellular proliferation,' is the subject of a report. "Wnts are secreted lipid-modified signaling proteins. Activation of Wnt signalling in many tissues has also been associated with cancer," scientists in Hunan, People's Republic of China report. "In many eukaryotes, expression of nuclear-encoded mRNA can be strongly inhibited by the presence of a small double-stranded RNA corresponding to exon sequences in the mRNA. In this study we used pAVU6+27 vectors, which have SalI and XbaI clone sites, to construct the siRNA expression vectors for human Wnt9a. Two kinds of small interfering RNA inserts were designed,...
Source: Cancer Weekly (2008-08-05)
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