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Leukemia Gene Therapy
Findings from Hamamatsu University, Department of Internal Medicine III advance knowledge in leukemia gene therapy
August 5th, 2008
New investigation results, 'KIS induces proliferation and the cell cycle progression through the phosphorylation of p27Kip1 in leukemia cells,' are detailed in a study published in Leukemia Research. According to recent research from Hamamatsu, Japan, "CEM, MOLT4 and SUP-B15 cells were transduced with lentivirus-mediated siRNA KIS gene. The mRNA expressions of KIS were successfully reduced in all cell lines." "On the other hand, the mRNA expressions of p27(Kip1) in CEM, MOLT4 and SUP-B15 cells were not affected by the transduction with siRNA KIS gene. We showed that KIS protein directly interacted with p27(Kip1) protein, and reduction of KIS inhibited the S10...
Source: Cancer Weekly (2008-08-05)
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