Cancer Weekly
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Acute Lymphoblastic Leukemia
Data on acute lymphoblastic leukemia reported by researchers at Children's Hospital
August 5th, 2008
" Corticosteroids are a critical component of therapy for acute lymphoblastic leukemia (ALL) but are associated with late effects, such as osteoporosis. Risk factors remain poorly defined," researchers in the United States report. "Because CRHR1 polymorphisms have been associated with other corticosteroid effects, our goal was to define whether CRHR1 polymorphisms predict which patients with ALL are likely to develop bone mineral deficits. Patients and Methods The mean bone mineral density z scores of 309 long-term survivors of ALL were determined by quantitative computed tomography of the trabecular lumbar spine. We analyzed whether CRHR1 genotypes, adjusted for sex,...
Source: Cancer Weekly (2008-08-05)
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