Cancer Weekly
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Acute Myeloid Leukemia
Reports on acute myeloid leukemia findings from Karolinska University provide new insights
August 5th, 2008
"An internal tandem duplication of FLT3 (FLT3/ITD) occurs in approximately 25% of newly diagnosed AML. PKC412 inhibits the growth of leukemic cell lines with FLT3 mutations such as the MV4-11," scientists in Stockholm, Sweden report. "This study evaluated the in vitro effects of the combination of PKC412 and ara-C or daunorubicin, studying the effect of co-incubation, pre-incubation and sequential incubation of the drugs in patient samples and cell lines. Thirty-three patients with AML were included. Two cell lines were studied; MV4-11 that expresses the FLT3/ITD and HL-60 that does not. In the patient cells PKC412 exerted its effect at concentrations between 0.1 and...
Source: Cancer Weekly (2008-08-05)
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