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New life sciences study findings have been published by scientists at Nextcea, Inc.

Published in Cancer Weekly, August 5th, 2008

"Antibody-cytotoxic conjugates are complex novel therapeutic agents whose toxicological properties are not presently well understood. The objective of this study was to identify toxicological markers in serum that correlate with MLN8866 (an antibody-cytotoxic conjugate) exposure and related pathological events in monkeys," scientists in the United States report.

"Cynomolgus monkeys were treated once with 5, 15, or 30 mg/kg MLN8866 via a 20 min intravenous infusion. MLN8866 exposure (Cmax and AUC0-4 day) was determined by quantifying MLN8866 levels in serum. The increase in MLN8866 exposure was approximately dose proportional," wrote F.Y. Hsieh and colleagues, Nextcea,...

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