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Adrenocortical Cancer
New adrenocortical cancer research reported from La Sapienza University
August 5th, 2008
"Mitotane, 1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl) ethane (o,p'-DDD) is an agent with adrenotoxic effect, which is able to block cortisol synthesis. This drug and radiotherapy are used also in adrenal cancer treatment even if their biological action in this neoplasia remains unknown," researchers in Rome, Italy report. "We investigated the effects of o,p'-DDD and ionizing radiations (I R) on cell growth inhibition and cell cycle perturbation in H295R and SW13 adrenocortical cancer cells. Both cell lines were irradiated at a 6 Gy dose and were treated with o,p'-DDD 10(-5) M separately and with IR/o,p'-DDD in combination. This combination treatment induced an...
Source: Cancer Weekly (2008-08-05)
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