Cancer Weekly
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Cancer Weekly
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Amyotrophic Lateral Sclerosis
Reports outline amyotrophic lateral sclerosis study findings from Ajou University, Medical Department
August 5th, 2008
According to recent research from South Korea, "Cortical neurons deprived of serum undergo apoptosis that is sensitive to inhibitors of macromolecule synthesis. Proteomic analysis revealed differential expression of 49 proteins in cortical neurons 8 h after serum deprivation." "Tissue inhibitor of metalloproteinases-3 (TIMP-3), a proapoptotic protein in various cancer cells, was increased during serum deprivation-induced apoptosis (SDIA), but not during necrosis induced by excitotoxicity or oxidative stress. Levels of TIMP-3 were markedly increased in degenerating motor neurons in a transgenic model of fa milial amyotrophic lateral sclerosis. The TIMP-3 expression was...
Source: Cancer Weekly (2008-08-05)
|
