Cancer Weekly
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Angiogenesis
Research on angiogenesis described by scientists at New York University, Medical Department
August 5th, 2008
According to recent research from the United States, "Cathepsin D (CD) up-regulation has been associated with human malignancy and poor prognosis. Thrombin up-regulated CD mRNA and protein in eight tumor cell lines as well as in human umbilical vascular endothelial cells (HUVEC)." "Thrombin increased the secretion of CD by 3- to 8-fold and enhanced chemotaxis (similar to 2-fold) in 4T1 murine mammary CA cells, which was completely inhibited with the knockdown of CD. Secreted 4T1 CD induced neoangiogenesis by 2.4-fold on a chick chorioallantoic membrane, which was blocked in CD-KD cells. The addition of pure CD (2 ng) to the chick chorioallantoic membrane increased...
Source: Cancer Weekly (2008-08-05)
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