Published in Cancer Weekly, August 5th, 2008
"Here, we show that protein phosphatase 2A (PP2A), its regulatory subunit, alpha 4, and rapamycin, an inhibitor of the mammalian target of rapamycin kinase complex 1 (mTORC1), regulate the nuclear localization and transcriptional activity of GLI3. An increase in PP2A activity or treatment with rapamycin leads to cytosolic retention of GLI3 and, consequently,...
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