Cancer Weekly
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Brain Cancer
Findings from Duke University, Preston Robert Tisch Brain Tumor Center provide new insights into brain cancer
August 5th, 2008
"We determined the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) of imatinib mesylate, an inhibitor of the receptor tyrosine kinases platelet-derived growth factor receptor (PDGFR), the proto-oncogene product c-kit, and the fusion protein Bcr-Abl, when administered for 8 days in combination with temozolomide (TMZ) to malignant glioma (MG) patients. MG patients who had not failed prior TMZ were eligible to receive TMZ at a dose of 150-200 mg/m(2) per day on days 4-8 plus imatinib mesylate administered orally on days 1-8 of each 4-week cycle," scientists in the United States report. "Patients were stratified based on concurrent administration of...
Source: Cancer Weekly (2008-08-05)
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