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Cancer Weekly

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Cancer Gene Therapy



Nagasaki University, First Department of Internal Medicine details research in cancer gene therapy



August 12th, 2008

A report, 'Tum-1, a tumstatin fragment, gene delivery into hepatocellular carcinoma suppresses tumor growth through inhibiting angiogenesis,' is newly published data in International Journal of Oncology. "Since hepatocellular carcinoma (HCC) is a hypervascular cancer, anti-angiogenic therapy is a promising approach to treat HCC. In the present study, we investigated the antiangiogenic and antitumor effects of tum-1, a fragment of tumstatin, gene transduction into HCC in vitro and in vivo," researchers in Nagasaki, Japan report.

"Tum-1 gene was cloned into a pSecTag2B mammalian expression vehicle to construct pSecTag2B-tum-1. pSecTag2B-tum-1 or vehicle were...


Source: Cancer Weekly (2008-08-12)

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