Gene Therapy

Studies from University of Pittsburgh yield new information about gene therapy

Published in Cancer Weekly, August 12th, 2008

According to recent research from the United States, "Squamous cell carcinoma of the head and neck (SCCHN) is a leading cause of cancer deaths worldwide. Epidermal growth factor receptor (EGFR), an upstream mediator of signal transducer and activator of transcription (STAT)-3 is overexpressed in a variety of cancers, including SCCHN."

"Therapies such as monoclonal antibodies and tyrosine kinase inhibitors targeting EGFR have demonstrated limited antitumor efficacy, which may be explained, in part, by persistent STAT3 activation despite EGFR inhibition. STAT3 activation induces expression of target genes in SCCHN, including Bcl-X-L, a mediator of antiapoptotic activity....

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Source: Cancer Weekly (2008-08-12)

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