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Cancer Gene Therapy
Research from Children's Cancer Institute reveals new findings on cancer gene therapy
August 12th, 2008
New research, 'siRNA targeting the IRF2 transcription factor inhibits leukaemic cell growth,' is the subject of a report. According to recent research published in the International Journal of Oncology, "Interferon regulatory factor (IRF) 1 and its functional antagonist IRF2 were originally discovered as transcription factors that regulate the interferon-beta gene. Control of cell growth has led to the definition of IRF1 as a tumor suppressor gene and IRF2 as an oncogene." "Clinically, approximately 70% of cases of acute myeloid leukaemia demonstrate dysregulated expression of IRF1 and/or IRF2. Our previous studies have shown that human leukaemic TF-1 cells...
Source: Cancer Weekly (2008-08-12)
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