Oncogenetics

Reports on oncogenetics findings from M.S. Song and co-researchers provide new insights

Published in Cancer Weekly, August 12th, 2008

"The tumor suppressor RASSF1A is inactivated in many human cancers and is implicated in regulation of microtubule stability, cell cycle progression and apoptosis. However, the precise mechanisms of RASSF1A action and their regulation remain unclear," scientists writing in the journal Oncogene report.

"Here we show that Skp2, an oncogenic subunit of the Skp1-Cul1-F-box ubiquitin ligase complex, interacts with, ubiquitinates, and promotes the degradation of RASSF1A at the G1-S transition of the cell cycle. This Skp2-dependent destruction of RASSF1A requires phosphorylation of the latter on serine-203 by cyclin D-cyclin-dependent kinase 4. Interestingly, mutation of...

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Source: Cancer Weekly (2008-08-12)

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