Cancer Weekly
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Cancer Gene Therapy
New cancer gene therapy research from F. Wang and co-researchers described
August 12th, 2008
"RNA interference (RNAi) is an evolutionarily conserved process of gene silencing in multiple organisms, which has become a powerful tool for investigating gene function by reverse genetics. Herein, we constructed a short hairpin RNA (shRNA) lentiviral expression vector targeting a proliferation-inducing ligand (APRIL) gene in the CFPAC-1 cell (a type of cell strain of human pancreatic cancer) in order to observe the inhibitory effect of APRIL gene's shRNA on the growth of the CFPAC-1 cell in vitro and in vivo," researchers in Nantong, People's Republic of China report. "The results showed that lentivirus-mediated RNAi effectively inhibited the expression of APRIL mRNA...
Source: Cancer Weekly (2008-08-12)
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