Cancer Weekly
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Cancer Weekly
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Bone Research
Report summarizes bone research study findings from A. Bozec and co-researchers
August 12th, 2008
According to recent research from Madrid, Spain, "Osteoclasts are multinucleated haematopoietic cells that resorb bone. Increased osteoclast activity causes osteoporosis, a disorder resulting in a low bone mass and a high risk of fractures(1)." "Increased osteoclast size and numbers are also a hallmark of other disorders, such as Paget's disease and multiple myeloma(2). The protein c- Fos, a component of the AP- 1 transcription factor complex, is essential for osteoclast differentiation(3). Here we show that the Fos- related protein Fra- 2 controls osteoclast survival and size. The bones of Fra- 2- deficient newborn mice have giant osteoclasts, and signalling through...
Source: Cancer Weekly (2008-08-12)
|
