Cancer Weekly
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Breast Cancer
Investigators at Emory University have published new data on breast cancer
August 12th, 2008
"The HER2 receptor tyrosine kinase is amplified and/or overexpressed in approximately 30% of metastatic breast cancers. Interactions and cross signaling from the HER2 receptor to other growth factor receptors may potentially contribute to therapeutic resistance," researchers in the United States report. "In this review, we discuss HER2 receptor cross talk with the estrogen receptor and implications toward resistance to endocrine therapies. We also review mechanisms of resistance to the HER2-targeted antibody trastuzumab, including signaling from other members of the HER family, increased signaling through the PI3-kinase pathway, and cross talk from the insulin-like...
Source: Cancer Weekly (2008-08-12)
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