Cancer Gene Therapy

Studies from Nankai University have provided new data on cancer gene therapy

Published in Cancer Weekly, August 12th, 2008

According to a study from Tianjin, People's Republic of China, "G250 is a tumor associated antigen that is found on > 90% of renal cell carcinoma (RCC). In order to develop a highly targeting gene vector for RCC gene therapy, G250 monoclonal antibody was prepared, purified and characterized."

"The antibody was chemically bound to Polyethylenimine (PEI) to form the IgG-PEI conjugate. The conjugate is capable of forming DNA complexes in the size of nano meters and with a narrow size distribution. The targeting effect and transfection efficiency were tested on five cell lines, ketr 3, Hela, ACHN, HepG2, and smooth muscle cells. The transfection was quantitatively...

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Source: Cancer Weekly (2008-08-12)

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