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Apoptosis
Reports by C.H. Tian and co-researchers describe recent advances in apoptosis
August 19th, 2008
"Intracellular redox homeostasis plays a critical role in determining tumor cells' sensitivity to drug-induced apoptosis. Here we investigated the role of thioredoxin-1 (TRX1), a key component of redox regulation, in arsenic trioxide (As2O3)-induced apoptosis," researchers in Beijing, People's Republic of China report. "Over-expression of wild-type TRX1 in BepG(2) cells led to the inhibition of As2O3-induced cytochrome c (cyto c) release, caspase activation and apoptosis, and down-regulation of TRX1 expression by RNAi sensitized HepG(2) cells to As2O3-induced apoptosis. Interestingly, mutation of the active site of TRX1 from Cys(32/35) to Ser(32/35) converted this...
Source: Cancer Weekly (2008-08-19)
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