Cancer Weekly
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Cancer Gene Therapy
Studies conducted at Kyushu University on cancer gene therapy recently published
August 19th, 2008
According to recent research published in the journal Bioscience Biotechnology and Biochemistry, "We constructed a novel cancer-specific regulatable adenoviral expression system comprising two vectors: one expressing rtTA, a reverse tetracycline transactivator regulated by the human telomerase reverse transcriptase (hTER7) gene promoter, the other expressing the target gene regulated by the tetracycline response element (TRE). rtTA transactivates target gene expression in the presence of doxycycline." "Using these vectors, we constructed an adenoviral expression system, the Tel-On system, which enables highly efficient target gene transduction," wrote M. Udono...
Source: Cancer Weekly (2008-08-19)
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