Cancer Weekly
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Cancer Gene Therapy
Research conducted at China University has updated our knowledge about cancer gene therapy
August 26th, 2008
" Adeno-associated virus (AAV) has rapidly become a promising gene delivery vehicle for its excellent advantages of low pathogenicity and long-term gene expression. However, lack of tissue specificity caused low efficiency of AAV transfer to target cells," scientists in Shanghai, People's Republic of China report. "The promoter of human telomerase reverse transcriptase (hTERT) has been implicated in mediating gene expression in cancer cells as hTERT is transcriptionally upregulated in most cancer cells. Thereby, the hTERT promoter becomes a good candidate to enhance the targeting efficiency of AAV in cancer cells. Tumor necrosis factor-related apoptosis-inducing ligand...
Source: Cancer Weekly (2008-08-26)
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