Cancer Weekly
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Cancer Gene Therapy
Research reports on cancer gene therapy from Y.H. Li and colleagues provide new insights
August 26th, 2008
According to a study from Beijing, People's Republic of China, "Tumor growth and metastasis depend critically on blood vessel formation. Antiangiogenesis, therefore, represents a promising strategy for cancer therapy." "The kringle 5 (K5) domain of human plasminogen is a potent angiogenesis inhibitor. To investigate whether intramuscular electroporation (EP) of K5 has antitumor activity in mouse tumor models, we constructed a plasmid encoding K5 (pVAX1-K5). Hela cells transfected with this plasmid produced and secreted K5 that inhibited the migration of human microvascular endothelial cells. Intramuscular EP treatment of pVAX1-K5 inhibited the growth of Lewis lung...
Source: Cancer Weekly (2008-08-26)
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