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Cancer Gene Therapy
Nova Southeastern University, Department of Pharmaceutical Sciences details research in cancer gene therapy
August 26th, 2008
A report, 'Identification of HDM2 as a regulator of VEGF expression in cancer cells,' is newly published data in Life Sciences. "Overexpression of vascular endothelial growth factor (VEGF) and the extent of neoangiogenesis are closely correlated with tumor development and cancer metastases. To assess whether VEGF mediated angiogenesis is regulated by HDM2, we treated the GI-101A and HL-60 cells with HDM2 gene specific antisense phosphorothioate oligodeoxynucleotide (AS5)," researchers in the United States report. "The antisense treatment resulted in a significant reduction of both basal as well as phorbol 12,13-dibutyrate (PDB) and Diethylstilbestrol (DES)...
Source: Cancer Weekly (2008-08-26)
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