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Cancer Weekly

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Cancer Gene Therapy



Study data from University of Sao Paulo, Institute of Biomedical Science update understanding of cancer gene therapy



August 26th, 2008

Fresh data on cancer gene therapy are presented in the report 'Adhesion and protease activity in cell lines from human salivary gland tumors are regulated by the laminin-derived peptide AG73, syndecan-1 and beta1 integrin.' According to a study from Sao Paulo, Brazil, "We studied the induction of protease activity by the laminin alpha1-derived peptide AG73 in cells from adenoid cystic carcinoma (CAC2) and myoepithelioma (M1), respectively a malignant and a benign salivary gland tumors. Laminin alpha1 chain and MMP9 were immunolocalized in adenoid cystic carcinoma and myoepithelioma in vivo and in vitro."

"Cells grown inside AG73-enriched laminin-111 exhibited large...


Source: Cancer Weekly (2008-08-26)

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